At Opterion, our mission is to relentlessly innovate for those living with chronic kidney disease, creating breakthrough therapies that put patients first — because every person deserves a future free from the burdens of outdated treatments.
A Health CrisisHiding in Plain Sight
Kidney disease affects millions of people worldwide, with many patients ultimately requiring dialysis.
Living with kidney disease worldwide—and growing ~8% per year.
3rd Fastest-Growing Cause of Death
Ranking among the top mortality drivers worldwide and still rising.
A Chronic & Progressive Disease
Fueled globally by the rising rates of diabetes, hypertension, and obesity.
~7% of U.S. Medicare Spend
Consuming a massive portion of the healthcare budget to treat less than 1% of the population.
30+ Years Without Innovation
The burden of disease has grown, but treatment technology has lagged for decades.
Treating Kidney Disease
For people living with chronic kidney disease, treatment options are limited and life-altering. Improving Peritoneal Dialysis (PD) represents a compelling opportunity to enhance patients' lives while enabling a scalable, cost-effective model for healthcare systems.
Most patients rely on in-center hemodialysis, which is time-consuming, physically demanding, and highly disruptive to daily life. While Peritoneal Dialysis (PD) offers a gentler, at-home alternative linked to better early outcomes, it has seen little innovation in decades. Today's PD is constrained by outdated, glucose-based solutions that cause metabolic stress and limit long-term use.
OPT101 is a novel, non-glucose-based osmotic agent designed to address the significant limitations of current PD therapies – improving outcomes and quality of life for patients with advanced chronic kidney disease (CKD).
At glance
Reduces glucose-related complications
Designed for fewer metabolic side effects
Designed to be a well-tolerated long-term treatment
Designed for all daily dwells
Program progressing, with first data anticipated in mid-2026
Delivers rapid and sustained ultrafiltration across both day and night dwells.
Metabolically safer dialysis
Designed to minimize glucose spikes and metabolic distress.
Customizable osmotic strength
Designing multiple concentrations to allow for highly personalized therapy.
Protects kidney function
A gentler alternative that actively preserves the patient's residual kidney function.
Extended treatment duration
Designed to prevent the peritoneal damage caused by glucose, extending the window for PD treatment.
Greater flexibility and freedom
Empowers patients to safely manage their treatment at home, at work, or while traveling.
Join us and be part of our team
We are always looking for dedicated and curious individuals who want to contribute to our mission of advancing breakthrough therapies for patients with chronic kidney disease. Join us and be part of our pioneering spirit.