CKD & Burden of Disease
Chronic kidney disease (CKD) is a major global disease burden and leads to substantial worldwide morbidity and mortality. An estimated 5–10 million people die annually from kidney disease1.
Due to the constant rise of risk factors of CKD, such as diabetes, obesity and hypertension, the prevalence of CKD is also increasing: the estimated number of disability-adjusted life years attributable to kidney disease globally increased from 19 million in 1990 to 33 million in 20132. CKD mostly develops over years and often progresses to end-stage renal disease (ESRD), requiring costly renal replacement therapy in the form of dialysis or transplantation.
1 https://www.who.int/bulletin/volumes/ 96/6/17-206441.pdf
2 https://www.thelancet.com/journals/lancet /article/PIIS0140-6736(15)61340-X/fulltext
Current and projected prevalence of kidney failure requiring kidney replacement therapy
Growth is continuously outpacing the capacity of kidney replacement therapy (KRT), defined as maintenance dialysis or kidney transplant, especially in low-income and middle-income countries.
- National prevalence of peritoneal dialysis (# of patients).
- Estimated worldwide need and projected capacity for KRT by 2030. pmp, per million population.
Adapted with permission from the ISN Global Kidney Health Atlas 2019
- USRDS 2020 ESRD Report, Tang 2020 Dialysis in Asia, Chen 2020 Kidney tx in China, anzdata 2020, Zakharova 2018 Kidney Tx in Russia,
- Himmelfarb et al., ‘The current and future landscape of dialysis’, Nature Reviews, July 2020